Conversion of a Gemistocytic Astrocytoma to a Fibrillary Astrocytoma after Temozolomide and Radiation Therapy

Conversion of a Gemistocytic Astrocytoma to a Fibrillary Astrocytoma after Temozolomide and Radiation Therapy

In most instances, gemistocytic astrocytoma progresses to anaplastic astrocytoma at the time of recurrence. Here, we report an unusual case where a gemistocytic astrocytoma converted to a more benign fibrillary histology after temozolomide/radiation therapy. We present the case of a 26-year-old woman with a history of fibrillary astrocytoma that was followed over a span of eight years and under...

Cerebral astrocytoma in a sheep

Astrocytoma as one of the most common central nervous system (CNS) tumors is rarely reported in veterinary literature. A 7-year-old Persian Lori-Bakhtiari ewe was presented to the clinic with a two months history of progressive blindness, nystagmus to the right, bilaterally decreased pupillary reflexes, head pressing and paddling. At necropsy, a whitish well-circumscribed mass with dimensions o...

***CASE REPORT*** Gliosarcoma after diagnosis of fibrillary astrocytoma

Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocytoma

BACKGROUND Malignant gliomas recur even after extensive surgery and chemo-radiotherapy. Although a relatively novel chemotherapeutic agent, temozolomide (TMZ), has demonstrated promising activity against recurrent glioma, the effects last only a few months and drug resistance develops thereafter in most cases. Induction of O6-methylguanine-DNA methyltransferase (MGMT) in tumors is considered to...

Survival of patients treated with radiation therapy for anaplastic astrocytoma

BACKGROUND Anaplastic astrocytoma (AA) represents 7% of primary brain tumors in adults. Patient-, tumor-, and treatment-related factors are thought to be predictive of survival. We retrospectively assessed the association of patient-, tumor-, and treatment-related factors with survival in AA treated with radiotherapy (RT) at our institution. PATIENTS AND METHODS Medical records of patients wi...